Jupiters Oberfläche 1905-06

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905

Atmospheric escape from hot Jupiters

The extra-solar planet HD209458b has been found to have an extended atmosphere of escaping atomic hydrogen (Vidal-Madjar et al. 2003), suggesting that “hot Jupiters” closer to their parent stars could evaporate. Here we estimate the atmospheric escape (so called evaporation rate) from hot Jupiters and their corresponding life time against evaporation. The calculated evaporation rate of HD209458...

Two Classes of Hot Jupiters

We identify two classes of transiting planet, based on their equilibrium temperatures and Safronov numbers. We examine various possible explanations for the dichotomy. It may reflect the influence of planet or planetesimal scattering in determining when planetary migration stops. Another possibility is that some planets lose more mass to evaporation than others. If this evaporation process pref...